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S1E186 Chimeric GPCRs: Why the Easy Designs Fail — Charlotte Crauwels
What if two nearly identical GPCRs make a worse chimera than two receptors from completely different classes? Charlotte Crauwels is building computational tools to find out why — and to predict which…
S1E185 The Beta-2 Agonist That Doesn't Stop Working — Tore Bengtsson
Every beta-2 agonist ever tested for muscle growth hits the same wall: desensitization. Dr. Tore Bengtsson built one that doesn't.A professor at Stockholm University and founder of Atrogi, Dr.…
S1E184 One Molecule, Two Opioid Receptors - Joseph Kim
Dr. Joseph Kim solved cryo-EM structures of mu and kappa opioid receptors bound to the same small molecule — and found it does something different at each one.In this conversation, Dr. Kim walks…
S1E183 Can Simulations Predict GPCR Ligand Bias?
How does ligand binding at the extracellular pocket of a GPCR reshape signaling on the intracellular side?Biased agonism is often measured through pathway activation assays, but the structural origin…
S1E182 Why Mosquitoes Hunt You: The GPCR Behind the Bite - Laura Duvall
Conserved neuropeptide Y GPCRs orchestrate both feeding and mating behaviors in mosquitoes, with direct translational parallels to human gut-brain signaling.Quick SummaryLearn how receptor…
S1E181 GPCR Location and Lipid Raft Signaling
Key TakeawaysHow does the precise localization of GPCRs in lipid rafts reshape drug discovery strategy? Examine implications for functional assays and therapeutic innovation.Explore the pivotal role…
S1E180 Choosing the Right GPCR Assays for Translational Drug Discovery 180
Episode SummaryPotent in vitro hits often fail in vivo—Martin Marro details how robust assay choice and pathway deconvolution can revive GPCR drug discovery programs.Listeners will learn practical…
How Academia–Industry Collaboration Is Scaling GLP-1 Receptor Tools | Dr. GPCR Podcast #179
GPCR tools don’t move the field forward unless researchers can actually use them. This episode breaks down how collaboration turns probes into progress.SummaryIn the final episode of this series,…
Imaging GPCRs in Action: Chemical Probes for Next-Level Discovery | Dr. Johannes Broichhagen #178
Chemical probes are reshaping how we map GLP-1R in real time — revealing receptor pools antibodies can’t reliably capture.This is Episode 2 of a 3-part GPCR tool-development series created in…
Mapping GLP-1 & GIP Receptors in Metabolic Disease with Dr. David Hodson - Episode 177
Precise receptor mapping is reshaping how we understand incretin biology. David Hodson explains how GPCR-targeted chemical probes reveal where GLP-1 and GIP receptors actually signal across pancreas…
Inside Monash: Organized Signaling, Real Impact
What makes Monash a model for modern pharmacology? Dr. Michelle Halls reveals how collaboration, mentorship, and receptor organization shape today’s GPCR breakthroughs — from femtomolar signaling to…
S1E175 Model. Predict. Discover. with Dr. Jens Carlsson | Dr. GPCR Podcast #175
Predicting, not just explaining, can change how we design GPCR-targeted drugs. Jens Carlsson reveals how modeling bridges structure, function, and pharmacology.Hear how predictive simulations shape…
S1E174 From Rare Earth Probes to Internalization Assays: The pHSense Story with Dr. Eric Trinquet from Revvity | Dr. GPCR Podcast #174
🔬 What if you could track GPCR internalization—no wash, high-throughput, and in endogenous systems?Discover how Dr. Eric Trinquet and Revvity built pH Sense, a next-gen fluorescence assay that…
S1E173 From Curiosity to Breakthrough: Ajay Yekkirala on GPCR Innovation | Dr. GPCR Podcast #173
What if a failed med school plan led to a biotech breakthrough?Ajay Yekkirala shares how GPCRs, AI, and scientific curiosity are reshaping pain therapeutics — and what it really takes to build better…
S1E172 Xylazine, Fentanyl, and the Fight for Breath with Catherine Demery
When fentanyl slows your breath and xylazine traps it, the clock starts ticking.PhD candidate Catherine Demery takes us inside her fight to understand how fentanyl and xylazine shut down breathing in…
Smells Like GPCR Spirit: Cracking Olfactory Codes with Alessandro Nicoli / Dr. GPCR Podcast #171
Watch the video version of this podcast episode.https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-171-with-alessandro-nicoli---------------------------------Become a #DrGPCR Ecosystem…
S1E170 GPCRs and the Science Behind Pain & Recovery with Dr. Alex Serafini / Dr. GPCR Podcast #170
Watch the video version of this podcast episode.https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-170-with-dr-alex-serafini---------------------------------Become a #DrGPCR Ecosystem…
S1E169 GPCR Pharmacology, Career Twists & Serendipity with Dr. Sokhom Pin / Dr. GPCR Podcast #169
Watch the video version of this podcast episode.https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-169-with-dr-sokhom-pin---------------------------------Become a #DrGPCR Ecosystem…
S1E168 Baking Molecules, Building Probes: When Chemists Think Like Biologists with Dr. Maria Majellaro / Dr. GPCR Podcast 168
Watch the video version of this podcast episode:https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-168-with-dr.-maria-majellaro-from-celtarysVisit Celtarys' website in the Ecosystem:…
S1E167 Hacking GPCRs: Tools, Tech & Drug Discovery w/ Drs. Tom Sakmar & Ilana Kotliar / Dr.GPCR Podcast 167
Watch the video version of this podcast episode.https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-167-with-tom-sakmar-%26-ilana-kotliar---------------------------------Become a #DrGPCR Ecosystem…
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Dr. GPCR Podcast has published 224 episodes since May 2020, covering topics in Life Sciences, Science.
Dr. GPCR Podcast is currently highly active with new episodes every 2 weeks. Average episode length is 59m.
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