Episodes 25
Avg. Duration 1h 14m
Activity Declining
Since Jan 2024
Latest Episode Apr 2026

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Publishing Details

Schedule
Every 2 Weeks
Format
Episodic
Consistency
3%
Hosting
api.substack.com

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About This Podcast

Spotlighting the world’s most ambitious biotech founders, investors, researchers and change-makers.

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Recent Episodes

Building Science's Missing Infrastructure — Adam Marblestone | Frameshifts Episode #11

Apr 02, 2026 1h 25m

Many of science’s most important projects fall through the cracks between academia and industry. These are the foundational tools that could accelerate entire fields, and yet don’t fit neatly into a…

Why 92% of Your Proteins Are Invisible — Parag Mallick | Frameshifts Episode #10

Dec 17, 2025 1h 17m

Parag Mallick is a Stanford Professor and Chief Scientist at Nautilus Biotechnology, a publicly traded biotech company. He’s also a professional magician and circus performer, which might sound…

Building the Wyss Institute, Organs-on-Chips, and Fighting for Science — Don Ingber | Frameshifts Episode #9

Dec 02, 2025 1h 16m

The future of human biology isn’t about better animal models - it’s about building human organs on chips that think like the body does.Don Ingber, founding director of Harvard’s Wyss Institute, has…

Shelby Newsad: Why Platforms Fail, What Founders Need, and Where Biotech Wins | Frameshifts Episode #8

Nov 25, 2025 1h 6m

This week, I sat down with Shelby Newsad, Partner at Compound VC, to break down what makes a great biotech investment and why so many platform stories fall short.Shelby lays out a playbook forged…

Space Travel, AI, and Immortality — Peter Diamandis | Frameshifts Episode #7

Nov 18, 2025 1h 11m

What happens when the man who launched commercial spaceflight decides humanity needs to stop aging?Peter Diamandis is building the infrastructure to tackle aging. He founded the XPRIZE Foundation,…

Minimally Invasive Neurosurgery, Brain-Computer Interfaces, and Continuous Pupil Monitoring — Theodore Schwartz

Nov 11, 2025 1h 25m

What happens when one of the world’s leading neurosurgeons steps away from the operating room to become a first-time founder? Dr. Theodore Schwartz pioneered minimally invasive brain surgery going…

Michael Florea: Smart Cages, AAV Cocktails & The Future of Longevity Research | Frameshifts Episode #5

Nov 04, 2025 1h 21m

This week, I sat down with genome engineering prodigy Michael Florea.I first met Michael at the Longevity Biotech Fellowship retreat in Tahoe National Forest, California (2.5hrs east of SF). I was in…

Virtual Cells, Programmable Biology, and the Quest to Hack Human Aging — Omar Abudayyeh & Jonathan Gootenberg

Oct 09, 2025 1h 24m

This week, I sat down with Omar Abudayyeh and Jonathan Gootenberg, the co-PIs who helped pioneer the field of genome engineering, and are now leading one of the most innovative and productive…

Francisco LePort & Martin Borch Jensen: The Biotech Founders Testing 25 Drugs in One Horse | Frameshifts Episode #3

Oct 01, 2025 1h 21m

In this week’s episode, I sit down with Francisco LePort and Martin Borch Jensen, the co-founders of Gordian Biotechnology. Gordian is revolutionizing drug discovery by testing where it matters most……

Ron Weiss: Building Biological Neural Networks to Fight Cancer | Frameshifts Episode #2

Sep 24, 2025 1h 18m

In this week's episode, I sit down with Prof. Ron Weiss, the MIT pioneer who helped create the field of synthetic biology. We discussed the emergence of living therapeutics that can think, adapt, and…

Kevin Esvelt: Sculpting Evolution, Engineered Viruses and Safeguarding Biotechnology | Frameshifts Episode #1

Sep 11, 2025 1h 21m

“What I wanted to do was harness evolution as effectively as possible.”In this episode, I sit down with pioneering synthetic biologist Kevin Esvelt. Together, we explore how technologies like gene…

Eldin Rostom: Biotech Entrepreneurship and Becoming a Dad | Insane Ambition Episode #14

Jul 18, 2024 1h 22m

Forbes 30 Under 30 honoree, Eldin Rostom, CEO and Co-Founder of Diag-Nose.io, who is pioneering the way forward in the diagnosis of chronic nasal disorders. In this episode, Eldin recounts his…

Joe Foster: Founding Reebok & Building a Globally Recognised Brand | Insane Ambition Episode #13

Jul 04, 2024 1h 4m

Meet Joe Foster, founder of Reebok, who revolutionised the sportswear industry by building a multi-billion dollar shoe empire. In this episode, Joe recalls his earliest memories of war, shares…

Ethan Donati: From Social Anxiety to hosting the World's Top Speakers | Insane Ambition Episode #12

Jun 20, 2024 52m

In this episode, we sit down with Ethan Donati, a marketing expert who overcame social anxiety to host some of Australia's largest events. Ethan shares his journey from a shy individual to a…

Michael Batko: Rethinking Startups & Shaping Tomorrow's Tech Giants | Insane Ambition Episode #11

Jun 06, 2024 55m

Step into the world of startup transformation with Michael Batko, the visionary CEO behind Startmate. With a track record of nurturing 230+ startups valued at over $2 billion, Startmate is a catalyst…

Jane Gunn: Future of Australia’s Health System & Primary Care Crisis | Insane Ambition Episode #10

May 23, 2024 1h 9m

Joining us is the inaugural chair of Primary Care Research at Royal Melbourne Hospital, Jane Gunn. Known not only as a medical practitioner and PhD graduate, Jane is also the Dean of the Faculty of…

James Fallon: MedTech, New Cure for Crohn’s & State of Research Funding | Insane Ambition Episode #9

May 09, 2024 1h 15m

In a world where technology drives rapid advancements, James Fallon, Chief Technology Officer at the Bionics Institute, takes us on a journey through the realms of medical research. From his insights…

Peter Vranes: Skincare, Smart Patches, Medtech, Innovation | Insane Ambition Episode #8

Apr 25, 2024 1h 34m

🎙️Peter Vranes: Skincare, Smart Patches, Medtech, Innovation | Insane Ambition Episode #8Meet Peter Vranes, often likened to a modern-day Nikola Tesla in the realm of health technology. As the…

Liam Bussell: Marketing, Cryptocurrencies and the Future of Blockchain | Insane Ambition Episode #7

Apr 11, 2024 43m

Ever wondered how blockchain technology can shape our future? Dive into the captivating world of blockchain and fintech with Liam Bussell, Chief Marketing Officer at CloudTech Group, and a passionate…

Hunter Watkin: Venture Capital, Investment, and Startups in Emerging Technologies | Insane Ambition Episode #6

Mar 28, 2024 1h 8m

Venture capital may sound glamorous, but as Hunter Watkin knows, "statistically, the vast majority of startups will fail.” So how does Hunter, a VC at Rampersand, identify the unicorns among the…

Frequently Asked Questions

How many episodes does Frameshifts with Benjamin Arya have?

Frameshifts with Benjamin Arya has published 25 episodes since January 2024, covering topics in Life Sciences, Science.

Is Frameshifts with Benjamin Arya still active?

Frameshifts with Benjamin Arya is currently declining with new episodes every 2 weeks. Average episode length is 1h 14m.

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