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Recent Episodes
S2E43 Dr. Michael Blanton on Open Data, Galaxy Surveys, and the Future of Astronomy (EP 43)
Hosted by Lester Nare and Krishna Choudhary, this episode is the second interview in our ongoing collaboration series with Carnegie Observatories. Krishna sits down with Dr. Michael Blanton, the new…
S2E42 How Scientists Actually Study Dark Matter (EP 42)
Hosted by Lester Nare, this episode features astrophysicist Dan Gilman for a deep conversation on one of the biggest open questions in modern physics: what dark matter actually is. Starting from…
S2E41 Dr. John Mulchaey on Carnegie Science and the Future of Astronomy (EP 41)
Hosted by Lester Nare and Krishna Choudhary, this interview features John Mulchaey, the 12th President of Carnegie Science and former Director of the Carnegie Observatories. The conversation starts…
S2E40 Ant Scans, Lunar Chickpeas, Hidden Galaxies & Superconductivity (EP 40)
Hosted by Lester Nare and Krishna Choudhary, this rundown episode covers four new science stories at a high level: a huge new 3D ant imaging database built with synchrotron X-ray microtomography, a…
S2E39 The Prometheus Constellation: Dramaturgical and Scientific Analysis of the Physicists in Oppenheimer (EP 39)
Hosted by Lester Nare and Krishna Choudhary, this special episode ranks the 26 scientists shown in Christopher Nolan’s Oppenheimer by one standard only: their contribution to fundamental science.…
S2E38 Harder Than Diamond? The New Hexagonal Diamond Breakthrough (EP 38)
Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into one of the strangest and most hard-fought materials science stories in decades: the claim that researchers have finally…
S2E37 Artemis II: Deep Dive on the Moon Flyby, Earthset, and Reentry (EP 37)
Hosted by Lester Nare and Krishna Choudhary, this episode is a full deep dive on Artemis II as the crew returns from humanity’s first crewed lunar flyby in more than 50 years. Lester and Krishna…
S2E36 Artemis II, Claude Code Leak, iPhone Spyware & Project Hail Mary (EP 36)
Hosted by Lester Nare and Krishna Choudhary, this rundown episode covers five new science and tech stories at a high level: NASA’s Artemis 2 moon mission, what actually leaked in the Claude Code…
S2E35 Can AI Help Wake Coma Patients? The Science of Consciousness (EP 35)
Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into one of the hardest questions in neuroscience: what breaks in the brain during a coma, and can we figure out how to turn…
S2E34 AI Cancer Vaccines, Strange Fish, Ketamine, and Ancient Life (EP. 34)
Hosted by Lester Nare and Krishna Choudhary, this episode is a fast-moving science rundown covering four remarkable stories from across AI, genetics, neuroscience, and paleontology. We dig into the…
S2E33 Can Human Neurons Really Play Doom? The Science Behind Wetware (EP. 33)
Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into one of the strangest science stories of the year: a dish of human neurons allegedly learning to play Doom. We go back to…
S2E32 5,000-Year-Old Bacteria, Solar Storms, Dogs, and Meta’s AI War (EP. 32)
Hosted by Lester Nare and Krishna Choudhary, this is our first standalone rundown episode — a faster, looser format where we hit several stories we didn’t have room to turn into full deep dives. This…
S2E31 Optovolution: Teaching Proteins to Think Like Computers (EP. 31)
Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into a new synthetic-biology breakthrough out of EPFL: OptoEvolution. The big idea is simple but powerful — traditional…
S2E30 Can We Stop an Asteroid? The Physics Behind NASA’s DART Mission (EP. 30)
Hosted by Lester Nare and Krishna Choudhary, this episode is a full deep dive on planetary defense. We break down NASA’s DART mission, why the goal was never to “blow up” an asteroid but to gently…
S2E29 Astrobiology’s Biggest Survival Test + A Vaccine Against Everything? (EP. 29)
Hosted by Lester Nare and Krishna Choudhary, this episode starts in astrobiology with a fresh experimental challenge to one of the biggest objections to lithopanspermia: can life actually survive the…
S2E28 Dark Galaxies, Fuzzy Dark Matter, and an Alzheimer’s Breakthrough (EP. 28)
Hosted by Lester Nare and Krishna Choudhary, this episode has two main stories: an astrophysics update on a candidate “dark galaxy” in the Perseus Cluster (a halo that’s ~99.9% dark matter), and a…
S2E15 Dream Engineering, the Proton Radius Puzzle, and an ALS Breakthrough (EP. 27)
Hosted by Lester Nare and Krishna Choudhary, this episode has three main stories: interactive dream engineering (yes, two-way “communication” during lucid dreaming), the proton radius puzzle finally…
S2E26 Winter Olympics Deep Dive: Ice Physics, Performance Pressure, and Climate Change (EP. 26)
Hosted by Lester Nare and Krishna Choudhary, this episode is a Winter Olympics deep dive from first principles—physics, neuroscience, and climate science in one ride.• Why ice is slippery: the “water…
S2E25 Plants, Quantum Sensors, and Predicting Cancer Evolution (EP. 25)
Hosted by Lester Nare and Krishna Choudhary, this episode jumps from plant biochemistry to quantum metrology to cancer evolution. We start with a University of York breakthrough that solves a…
S2E24 Artemis II, Apollo, and the Physics of Going Back to the Moon (EP. 24)
Hosted by Lester Nare and Krishna Choudhary, this episode is a full-spectrum moonshot: why Artemis II matters, how the mission actually works (SLS, Orion, translunar injection, free-return…
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From First Principles has published 43 episodes since August 2025, covering topics in Science.
From First Principles is currently active with new episodes weekly. Average episode length is 1h 23m.
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