Gradient Dissent: Conversations on AI
Lukas Biewald
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S1E139 He Raised $70M to Cure Every Disease With AI | Samuel G. Rodriques, Edison Scientific
Samuel Rodriques left physics because there were no unsolved problems left.Instead, he built an AI scientist named Kosmos to cure every disease, solve aging, and map the human brain.In this…
S1E138 Uber, Nissan, and Mercedes Chose This Self-Driving Startup | Alex Kendall, Wayve
"Every vehicle is capable of driverless operation. That's clearly the steady state of where we're going."Wayve started in a rented house in Cambridge with $1.5M, a car in the garage, and an aim to…
S1E137 Why Netflix, Uber, and Spotify Never Lag: The Database Nobody Talks About | Aaron Katz
"Companies designing for agents, not humans, are going to get a lot of lift."ClickHouse started as an internal tool at Yandex. Today it's the database Anthropic, OpenAI, Meta and Tesla all run on.In…
S1E136 The $64M Bet on an AI That Has to Be Right | Carina Hong, CEO of Axiom
Formal verification already consumes years of human effort.In this episode, Lukas Biewald talks with Carina Hong, Founder & CEO of Axiom, about why verification is becoming the real bottleneck in…
S1E135 What a $42B Software Co. Really Spends on AI Tools
“I don't worry about being replaced by AI. I worry about being replaced by someone who's really good at using AI.”Atlassian has 10,000+ engineers currently split-testing the world’s top AI coding…
S1E134 Inside the $41B AI Cloud Challenging Big Tech | CoreWeave SVP
The future of AI training is shaped by one constraint: keeping GPUs fed.In this episode, Lukas Biewald talks with CoreWeave SVP Corey Sanders about why general-purpose clouds start to break down…
S1E133 Why Physical AI Needed a Completely New Data Stack
The future of AI is physical. In this episode, Lukas Biewald talks to Nikolaus West, CEO of Rerun, about why the breakthrough required to get AI out of the lab and into the messy real world is…
S1E132 The Engineering Behind the World’s Most Advanced Video AI
Is video AI a viable path toward AGI? Runway ML founder Cristóbal Valenzuela joins Lukas Biewald just after Gen 4.5 reached the #1 position on the Video Arena Leaderboard, according to community…
S1E131 The CEO Behind the Fastest-Growing AI Inference Company | Tuhin Srivastava
In this episode of Gradient Dissent, Lukas Biewald talks with Tuhin Srivastava, CEO and founder of Baseten, one of the fastest-growing companies in the AI inference ecosystem. Tuhin shares the real…
S1E130 The Startup Powering The Data Behind AGI
In this episode of Gradient Dissent, Lukas Biewald talks with the CEO & founder of Surge AI, the billion-dollar company quietly powering the next generation of frontier LLMs. They discuss Surge's…
S1E129 Arvind Jain on Building Glean and the Future of Enterprise AI
In this episode of Gradient Dissent, Lukas Biewald sits down with Arvind Jain, CEO and founder of Glean. They discuss Glean's evolution from solving enterprise search to building agentic AI tools…
S1E128 How DeepL Built a Translation Powerhouse with AI with CEO Jarek Kutylowski
In this episode of Gradient Dissent, Lukas Biewald talks with Jarek Kutylowski, CEO and founder of DeepL, an AI-powered translation company. Jarek shares DeepL’s journey from launching neural machine…
S1E127 GitHub CEO Thomas Dohmke on Copilot and the Future of Software Development
In this episode of Gradient Dissent, Lukas Biewald sits down with Thomas Dohmke, CEO of GitHub, to talk about the future of software engineering in the age of AI. They discuss how GitHub Copilot was…
S1E126 From Pharma to AGI Hype, and Developing AI in Finance: Martin Shkreli’s Journey
In this episode of Gradient Dissent, Lukas Biewald talks with Martin Shkreli — the infamous "pharma bro" turned founder — about his path from hedge fund manager and pharma CEO to convicted felon and…
S1E125 Inside Cursor: The future of AI coding with Co-founder Sualeh Asif
In this episode of Gradient Dissent, host Lukas Biewald talks with Sualeh Asif, the CPO and co-founder of Cursor, one of the fastest-growing and most loved AI-powered coding platforms. Sualeh shares…
S1E124 Inside the Dark Web, AI and Cybersecurity with Christopher Ahlberg CEO of Recorded Future
In this episode of Gradient Dissent, host Lukas Biewald talks with Christopher Ahlberg, CEO of Recorded Future, a pioneering cybersecurity company leveraging AI to provide intelligence insights.…
S1E123 AI, autonomy, and the future of naval warfare with Captain Jon Haase, United States Navy
In this episode of Gradient Dissent, host Lukas Biewald speaks with Captain Jon Haase, United States Navy about real-world applications of AI and autonomy in defense. From underwater mine detection…
S1E122 The rise of AI agents
In this episode of Gradient Dissent, host Lukas Biewald sits down with João Moura, CEO & Founder of CrewAI, one of the leading platforms enabling AI agents for enterprise applications. Joe shares…
S1E121 R1, OpenAI’s o3, and the ARC-AGI Benchmark: Insights from Mike Knoop
In this episode of Gradient Dissent, host Lukas Biewald sits down with Mike Knoop, Co-founder and CEO of Ndea, a cutting-edge AI research lab. Mike shares his journey from building Zapier into a…
S1E120 DeepSeek, Stargate and AI's $600 Billion Question with Sequoia's David Cahn
In this episode of Gradient Dissent, host Lukas Biewald sits down with David Cahn, partner at Sequoia Capital, for a compelling discussion on the dynamic world of AI investments. They dive into…
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Gradient Dissent: Conversations on AI has published 137 episodes since March 2020, covering topics in Business, Technology.
Gradient Dissent: Conversations on AI is currently highly active with new episodes monthly. Average episode length is 53m.
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