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Recent Episodes
S2 Letter from Beijing 2: Tsinghua University – #113
This special episode was recorded at Tsinghua University in Beijing, generally regarded as the top university in China. Our guests are 3 Americans studying and working at Tsinghua: Gabriel…
S2 AI Billionaire on Existential Risk: Jaan Tallinn
Jaan Tallinn is a tech billionaire and founding engineer of Skype who leverages his wealth to mitigate existential risks from artificial general intelligence (AGI). He co-founded the Future of Life…
S2 Embryo Selection and Frontier Genomics with Dr. Alex Young – #111
Dr. Alex Young, a statistical geneticist and assistant professor in the Human Genetics department at UCLA, joins Steve Hsu to discuss the cutting edge of genomic prediction. They cover his research…
S2 Iran War is the First Missile War (crossover with Seeking Truth From Facts podcast) – #110
Steve and Alf discuss the Iran War, emphasizing what itreveals about modern missile and anti-missile technology, drones, andthe implications for a US-China conflict in the Western…
S2 Dreamers and Doomers: Our AI future, with Richard Ngo – #109
Richard Ngo is an independent AI researcher and philosopher known forhis work on AGI safety and alignment. He recently resigned fromOpenAI, where he was a member of the Governance team focused…
S2 China, Acceleration, and Nick Land - with Matt Southey – #108
Matt Southey is an editor for an AI safety organization. He wrote his PhD dissertation on the philosophy of Nick Land. Matt's "A Brief History of Accelerationism" can be found here, and he recommends…
S2 Shenzhen is the Technology Capital of the World, with Taylor Ogan – #107
Recorded live in Shenzhen with Taylor Ogan, the founder and CEO ofSnowbull Capital, which invests in Chinese technology companies.Taylor on X:https://x.com/TaylorOganPrevious episodes with…
S2 AI DOOM: Jesse Hoogland of Timaeus
This is the second episode of our series based on interviews for the documentary film, Dreamers and Doomers, about the SF Bay Area in the last days before AGI. Steve interviews Jesse Hoogland,…
S2 Dreamers and Doomers: Jeremy Nixon at AGI House – #105
Jeremy Nixon is a prominent AI researcher, entrepreneur, and the co-founder of AGI House, a leading "hacker house" community for artificial intelligence developers in Silicon Valley. He studied…
S2 Industrial Maximalism and Its Discontents: Dan Wang on US-China Competition – # 104
Links:Breakneck: China's Quest to Engineer the Futurehttps://www.amazon.com/Breakneck-Chinas-Quest-Engineer-Future/dp/1324106034Dan's 2025 annual letterhttps://danwang.co/2025-letter/Related…
S2 Geopolitics 2026, crossover with Seeking Truth From Facts podcast – #103
Steve and Alf discuss geopolitical events of 2025 and what they expect in 2026.Links:Manifold episode with Han Feizi, Letter From…
S2 Polygenics and Machine SuperIntelligence; Billionaires, Philo-semitism, and Chosen Embryos – #102
This is a two-part episode. The first ~30m covers the most important 2025 breakthroughs in polygenic embryo screening, while the second 30m focuses specifically on AI capabilities at the frontier of…
S2 Theoretical Physics With Generative AI – #101
All but the last 20 minutes of this episode should be comprehensible to non-physicists.Steve explains where frontier AI models are in understanding frontier theoretical physics. The best analogy is…
S2 Jeffrey Epstein, Israel, and Elite Power, with Murtaza Hussain – #100
Murtaza Hussain is a reporter for Drop Site News, which has brokenimportant stories based on recently obtained Epstein emails. Hussainreports that Epstein had an “extensive relationship with…
S2 Jian Lian on China's Industrial Policy and Global Strategy – #99
Jian Lian is an expert on China's political economy, industrial development, and technological development. He graduated from Peking University with a bachelor's and master's degree in economics.…
S2 Scott Horton on the Russia Hoax and Ukraine War – #98
Scott Horton is the author of Provoked: How Washington Started the New Cold War with Russia and the Catastrophe in Ukraine. Horton is a libertarian and anti-war activist. He and Steve discuss the…
S2 AIs Win Math Olympiad Gold: Prof. Lin Yang (UCLA) – #97
Lin Yang is a professor of computer science at UCLA. Recently, he and his collaborator built an AI pipeline using commercial models such as Gemini, ChatGPT, and Grok that performed at the gold medal…
S2 The Global AI Race: Z.ai and the View from Beijing — #96
Zixuan Li is Director of Product and genAI Strategy at Z.ai. He was educated at Renmin and Tsinghua University in China, and at MIT and Carnegie Mellon. Z.ai has released frontier open source LLMs…
S2 Seeking Truth From Facts: Weeks Where Decades Happen — #95
This episode is a co-release with the Seeking Truth From Facts podcast: https://substack.com/@seekingtruthfromfactsThe theme of this episode derives from Lenin:“There are decades where nothing…
S2 Kyle Chan on the Future of US-China Competition — #94
Kyle Chan is a Postdoctoral Research Associate and Lecturer in Sociology at Princeton University. His research focuses on industrial policy, clean technology, and infrastructure with a regional focus…
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Manifold has published 164 episodes since January 2019, covering topics in Life Sciences, Natural Sciences.
Manifold is currently highly active with new episodes every 2 weeks. Average episode length is 1h 12m.
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