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Recent Episodes
S7E03: The ABCs of IBD
Inflammatory bowel disease (IBD) is a debilitating, lifelong condition that changes how people plan their entire lives. In this episode, KT Park, Global Head of Gastroenterology and Hepatology, and…
S7E02: Breakthroughs in MS
Breakthroughs in the last decade have transformed how we understand and treat multiple sclerosis (MS), but what will it take to stop the disease in its tracks? Pull up a stool with co-host Maria…
S7E01: The Wild World of Eyeballs
We’re kicking off season seven with an in-depth look at the wild world of ophthalmology, where scientists are pushing the boundaries of what’s possible for vision treatments. In this episode, co-host…
Season Seven Teaser
Your favorite science podcast is back! To kick off season seven of Two Scientists Walk Into a Bar, hosts Maria Wilson and Danielle Mandikian sit down to celebrate a decade of the podcast and look…
S6E07: Foundation Models and Agents
In our season six finale, we dive deeper into how artificial intelligence (AI) is shaping the future of drug discovery and scientific research. With remarkable scale and speed, AI models parse…
S6E06: Decoding Lung Disease
From our first breath, the air we breathe and our genes shape how our lungs function. It’s a complex interplay we began exploring in our season four episode “Take A Deep Breath: Treating Asthma.”…
S6E05: Cells at Work
Cell therapy holds immense potential to transform the way we treat conditions in oncology, ophthalmology, autoimmune disorders, and a wide range of other therapeutic areas. But how do these…
S6E04: The Power of Digital Twins
Digital twins are virtual models of real-world systems that have been gaining momentum as a powerful tool in drug discovery and development. We touched on this concept last season when we covered…
S6E03: New Frontiers in Cancer
Each season we discuss new, exciting breakthroughs in cancer research. With evolving technologies enhancing how we understand and target the underlying drivers of cancer, the journey to developing…
S6E02: AI and the Quest for New Antibiotics
We published our first episode on the threat of antibiotic resistance in 2016, and nearly a decade later, it remains one of the world’s most pressing health crises. Today, with advances in artificial…
S6E01: Digging Deeper into Obesity
As we kick off season six, we’re diving deeper into one of our most popular topics from last season – our evolving understanding of obesity. In this episode, co-host Maria Wilson unpacks the latest…
Season Six Teaser
Join Danielle Mandikian and Maria Wilson as they kick off season six of Two Scientists Walk Into A Bar. Hear what they’ve been up to in the past few months and enjoy a sneak preview of the exciting…
S5E09: AI and The Future of Medicine
Machine learning and generative AI are transforming the ways we live and work, but how do these tools fit into the landscape of drug discovery? In our season 5 finale, co-host Danielle Mandikian is…
S5E08: A Deep Dive into Drug Modalities
Small molecules, antibodies, gene therapies – there are so many types of medicines scientists can consider when developing a new treatment for a disease. In this episode, Karin Briner, Senior Vice…
S5E07: Organoids: From Dish to Discovery
Did you know that scientists can grow three-dimensional, miniature versions of human organs in a dish? These tiny in vitro models, known as organoids, are helping scientists to better understand…
S5E06: Cancer Conversations: Early Detection and Potent Solutions
To defeat cancer, we need to understand it better. How does it grow? How do we detect it early? And most importantly, how do we treat it? In this episode, co-host Maria Wilson chats with oncology…
S5E05: The Streets and Deets of Obesity
What drives metabolic conditions like obesity? In this special episode, co-host and cardiovascular disease expert Maria Wilson, gRED Executive Director and Cardiovascular and Metabolism Research…
S5E04: Engineering Therapeutic Antibodies
Antibodies are proteins produced by our immune system that neutralize or help destroy abnormal cells and foreign agents, like bacteria and viruses. However, their utility extends beyond our bodies’…
S5E03: No Delivery, No Drug
Many health conditions require medicines that can be delivered to specific parts of the body. For instance, someone with asthma requires medication that targets the lungs, while someone with a…
S5E02: Seeing Clearly: The Past, Present and Future of Eye Treatment
Imagine the eyes as cameras, where the cornea acts as the lens and the retina as the film. As with a camera, if something goes wrong in the eye, it needs to be fixed to address the specific problem…
Frequently Asked Questions
Two Scientists Walk Into a Bar has published 56 episodes since October 2016, covering topics in Science.
Two Scientists Walk Into a Bar is currently highly active with new episodes monthly. Average episode length is 30m.
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