PsyQ: Journal Club
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Recent Episodes
S1E41 Dementia in Severe Schizophrenia - PsyQ Episode 41
In this episode of PsyQ, we critically examine the etiology of cognitive decline in severe, extremely treatment-resistant schizophrenia (SETRS) through the lens of a 2026 JAMA Psychiatry cohort…
S1E40 Metabolic Psychiatry: Ketosis for TRD - PsyQ Episode 40
In this episode of PsyQ, we critically evaluate the recent randomized clinical trial by Gao et al. published in JAMA Psychiatry investigating the ketogenic diet (KD) as an adjunctive treatment for…
S1E39 Brain and Blood Biomarkers in MDD - PsyQ Episode 39
This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit upathak.substack.com
S1E38 In-Utero Antipsychotic Medication Exposure - PsyQ Episode 38
This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit upathak.substack.com
S1E37 The Psychic Tourniquet: Ultra-Low-Dose Buprenorphine for Acute Suicidality - PsyQ Episode 37
In this episode of PsyQ, we confront the "zone of danger" in acute suicidality—the critical lag period where standard antidepressants often fail to address immediate "psychache". Anchored by the…
S1E36 Cannabis Use Disorder and Adolescent Suicide Risk - PsyQ Episode 36
In this episode of PsyQ, we review a large national inpatient study examining the association between cannabis use disorder (CUD) and suicide attempts/self-harm among hospitalized adolescents in the…
S1E35 STEP-BD: The Efficacy of Adjunctive Antidepressants in Bipolar Depression
In this episode of PsyQ, we review the landmark STEP-BD randomized controlled trial evaluating the effectiveness of adjunctive antidepressant treatment for bipolar depression. We analyze the study's…
S1E34 TMS in Older Veterans with MDD - PsyQ Episode 34
This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit upathak.substack.com
S1E33 Switch vs. Augment: Rewriting the Rules for Geriatric TRD - PsyQ Episode 33
In this episode of PsyQ, we perform a forensic analysis of the landmark OPTIMUM trial, a study that fundamentally reshapes the treatment algorithm for resistant depression in older adults. We dissect…
Combination Antidepressants in Acute MDD: How Much Better Is “Better”? - PsyQ Episode 32
This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit upathak.substack.com
Childhood ADHD Is Not Benign: What 30 Years of Data Reveals - PsyQ Episode 31
In this episode, we break down a major longitudinal synthesis of seven North American cohort studies following children with ADHD into adulthood over 10–30 years. The data are striking: while full…
S1E30 Event-Driven Dosing: Rethinking Binge Drinking Treatment - PsyQ Episode 30
In this episode, we dissect a landmark 2022 randomized controlled trial published in the American Journal of Psychiatrythat challenges the traditional "daily dose" paradigm for treating Alcohol Use…
Ketogenic Psychiatry: Mental Health, Ketones, and Clinical Implications - PsyQ Episode 29
In this episode, we unpack the psychiatric relevance of the ketogenic diet through the lens of a recent and compelling systematic review and meta-analysis from JAMA Psychiatry. Join us as we explore…
Antidepressant Discontinuation: Separating Data from Dogma - PsyQ Episode 28
Antidepressant discontinuation is one of the most contentious topics in psychiatry, fueling both patient fear and clinical uncertainty. But what does the highest quality, placebo-controlled evidence…
Bush Francis Made Simple - PsyQ Episode 27
In this episode of PsyQ, our psych journal club dives deep into the Bush–Francis Catatonia Rating Scale (BFCRS), guided by the 2022 BFCRS Training Manual and its original 1996 validation study. We…
S26E1 Journal Club - Ketamine for Depression: Relief at a Price? - PsyQ Episode 26
In this week’s episode of PsyQ, we break down the American Journal of Psychiatry review “Ketamine for Depression, but at What Cost?” by Li and colleagues. Here we explore the balance between…
Psychedelic Psychiatry: MDMA, Psilocybin, and What Comes Next - PsyQ Episode 25
In this episode, we take a clinical look at psychedelic-assisted therapy — what it is, how it works, and where it’s headed. We cover MDMA for PTSD and psilocybin for depression, break down the…
S24E1 STAR*D Struck: Remission and the Future of Depression Treatment - PsyQ Episode 24
In this episode of PsyQ, we take a critical look at the evolution of major depression treatment over the past two decades. We start with the foundational Sequenced Treatment Alternatives to Relieve…
Six Days to Liftoff: BrainsWay’s 6-Day Accelerated Deep TMS (SWIFT Protocol) - PsyQ Episode 23
In this episode, we break down BrainsWay’s 6-day accelerated Deep TMS for major depression—how its iTBS, 5-sessions-per-day schedule compresses a month of treatment into 6 days with non-inferior…
Profit Over Patients: Private Equity in Psychiatry - PsyQ Episode 22
In this episode, we dissect the alarming 75.6% rise in private equity (PE) ownership of US psychiatric hospitals and unpack the central paradox from a landmark 2025 JAMA Psychiatry study: how do…
Frequently Asked Questions
PsyQ: Journal Club has published 41 episodes since April 2025, covering topics in Health & Fitness, Mental Health.
PsyQ: Journal Club is currently declining with new episodes weekly. Average episode length is 17m.
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