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Recent Episodes
Alexander Disease Research Update – Episode #30: 1) Speech-language impairments, and 2) GFAP concentrations in CSF and blood
Send a textAlbee Messing, Debra Levin, and Amy Waldman discuss the following recent publications: [01:27] Language Skills in Patients With Alexander Disease. American Journal of Speech-Language…
Alexander Disease Research Update - Episode #29: Genotype-phenotype correlations, or does variant predict course?
Send a textAlbee Messing and Amanda Nagy discuss the following recent publication: [01:42] Genotype-phenotype correlations of GFAP variants in type I Alexander disease subtypesMolecular…
Alexander Disease Research Update - Episode #28: GDF15, nausea, vomiting, and "failure to thrive"
Send a textAlbee Messing, Tracy Hagemann, and Abby Olsen discuss the following recent publication: [01:45] Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated…
Alexander Disease Research Update – Episode #27: Genotype-phenotype association for 14 GFAP variants
Send a textAlbee Messing, Mel Feany, and Natasha Snider discuss the following recent publication: Genotype-phenotype association for 14 GFAP variants in Alexander disease. Neurology: Genetics. 11,…
Alexander Disease Research Update – Episode #26: Changes in gene expression and cognitive function in the rat model
Send a textAlbee Messing, Tracy Hagemann, and Rob Berman discuss the following recent publication: [02:01] GFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with…
Alexander Disease Research Update – Episode #25: GFAP Variants in the UK Biobank - estimated prevalence of adult-onset AxD
Send a textAlbee Messing, Charlie Wade, and Mel Feany discuss the following recent publication: [01:50] Analysis of GFAP variants in UK Biobank suggests underdiagnosis or incomplete penetrance…
Alexander Disease Research Update – Episode #24: 1) iPS cell model with aberrant development and 2) unusual variant in GFAP affecting the eye
Send a textAlbee Messing and Natasha Snider discuss the following recent publications: [01:04] Aberrant neurodevelopment in human iPS cell-derived models of Alexander disease …
Alexander Disease Research Update - Episode #23: Albee Messing's presentation at the recent conference in Philadelphia
Send a textAlbee Messing’s presentation at the recent Alexander disease conference in Philadelphia, August 3, 2024. Send your questions and feedback to: [email protected] support research on…
Alexander Disease Research Update - Episode #22: 1) anesthesia and AxD, and 2) GFAP cross-linking to itself
Send a textAlbee Messing, Amy Waldman, and Natasha Snider discuss the following recent publications: [02:07] A retrospective observational cohort study of the anesthetic management and outcomes…
Alexander Disease Research Update - Episode #21: 1) Blood levels of GFAP, neurofilaments, and tau, and 2) planning for in-person conference in Philadelphia this summer.
Send a textAlbee Messing, Jenny Pearson, Natasha Snider, and Amy Waldman discuss the following recent publication and the conference planned for this summer in Philadelphia: [02:02] Plasma…
Alexander Disease Research Update - Episode #20: 3D bioprinting method for co-culture of neurons and astrocytes reveals new features of Alexander disease
Send a textAlbee Messing and Linghai Kong discuss the following recent publication: [01:52] 3D bioprinting of human neural tissues with functional connectivity. Cell Stem Cell 31:260-274.e7…
Alexander Disease Research Update - Episode #19: Giant Axonal Neuropathy and Alexander Disease
Send a textAlbee Messing, Rachel Battaglia, and Natasha Snider discuss the following publication: [00:59] Intermediate filament dysregulation in astrocytes in the human disease model of KLHL16…
Alexander Disease Research Update - Episode #18: 1) Quantitative MRI in rat model, and 2) Developmental milestones in cerebral form of AxD
Send a textAlbee Messing, Nick Stowe, JP Yu, and Amy Waldman discuss the following recent publications: [4:30] Stowe NA, Singh AP, Barnett BR, Yi SY, Frautschi PC, Messing A, et al.…
Alexander Disease Research Update - Episode #17: 1) new iPS cell line, 2) acetylation and GFAP, and 3) STAT3 as a key regulator driving GFAP accumulation
Send a textAlbee Messing, Rachel Battaglia, and Tracy Hagemann discuss the following recent publications: [01:45] A defined roadmap of radial glia and astrocyte differentiation from human…
Alexander Disease Research Update - Episode #16: Webinar - Guangping Gao lab
Send a textWebinar on the strategy and preliminary results for “AAV-mediated Gene Silencing for the Treatment of Alexander Disease” presented by Drs. Guangping Gao, Jun Xie, and Dominic Gessler from…
Alexander Disease Research Update - Episode #15: subclassifications of Type I; questions regarding 1) mesenchymal stem cells and 2) the intransasal route of delivery
Send a textAlbee Messing and Davide Tonduti discuss the following recent publication: [00:41] Type I Alexander Disease: Update and Validation of the Clinical Evolution-Based…
Alexander Disease Research Update - Episode #14: whole exome/genome sequencing; more questions on the brainstem
Send a textAlbee Messing and Josh Bonkowsky discuss the following recent publication: [02:13] Identification of a novel de novo pathogenic variant in GFAP in an Iranian family with Alexander…
Alexander Disease Research Update - Episode #13: MRI diffusion tractography - what can it tell us?
Send a textAlbee Messing, Emi Takahashi, Arastoo Vossough, and Amy Waldman discuss the following recent publication: [02:03] Identification of association fibers using ex vivo diffusion…
Alexander Disease Research Update - Episode #12: GFAP variants and oxidative stress/mitochondrial dysfunction; commentary on dizziness, risks of brain biopsies
Send a textAlbee Messing, Rachel Battaglia, and Abby Olsen discuss the following recent publication: [01:00] Alexander disease GFAP R239C mutant shows increased susceptibility to lipoxidation…
Alexander Disease Research Update - Episode #11: neurology 101 (location, location, location), discussion on the autonomic nervous system
Send a textAlbee Messing and Abby Olsen discuss the following recent publication: [03:04] Adult-onset Alexander disease: new causal sequence variant in the GFAP gene. (Neurology: Genetics, in…
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Alexander Disease Research Update has published 30 episodes since July 2021, covering topics in Health & Fitness, Medicine.
Alexander Disease Research Update is currently highly active with new episodes every 2 months. Average episode length is 25m.
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