JACC Deep Dive
American College of Cardiology
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The STEP Trial and the Importance of Early Intensive Blood Pressure Control | JACC Deep Dive
Dr. Harlan Krumholz reviews the STEP trial, which studied over 8,500 older adults in China to compare intensive versus standard blood pressure control. The trial found that lowering systolic blood…
Percutaneous Mechanical Aspiration: A New Frontier in Endocarditis Care | JACC Deep Dive
In this episode of JACC Deep Dive, Editor-in-Chief Dr. Harlan Krumholz explores groundbreaking findings from the CLEAR-IE registry—the largest study to date on percutaneous mechanical aspiration…
Understanding Angina Symptom Trajectories After Invasive vs. Conservative Treatment | JACC Deep Dive
In this JACC Deep Dive, Dr. Harlan Krumholz highlights a study by Ikemura et al. that used data from the ISCHEMIA trial to model how angina symptoms evolve over three years in patients with stable…
Tirzepatide in HFpEF and Obesity: Consistent Benefits Regardless of Diabetes Status | JACC Deep Dive
In this JACC Deep Dive, Dr. Harlan Krumholz discusses a pre-specified analysis from the SUMMIT trial, which evaluated the effects of tirzepatide in patients with heart failure with preserved ejection…
Environmental Exposure as Intervention: HEPA Filtration and Blood Pressure Near Traffic Corridors | JACC Deep Dive
In this Deep Dive, Editor-in-Chief Dr. Harlan Krumholz explores a pragmatic, randomized crossover trial testing whether in-home HEPA filtration can reduce blood pressure in adults living near…
Master DAPT | JACC Deep Dive
In this episode of JACC Deep Dive, Dr. Harlan Krumholz explores new insights from a post hoc analysis of the MASTER DAPT trial, highlighting the real-world burden of ischemic and bleeding events in…
Cardiac Biomarkers in ATTR-CM From HELIOS-B | JACC Deep Dive
In this episode of JACC Deep Dive, KACC Editor-in-Chief Harlan M. Krumholz, MD, SM, FACC, explores a post hoc analysis of the HELIOS-B trial, which examined whether echocardiographic parameters can…
Insights From the INTERASPIRE Study | JACC Deep Dive
JACC focuses in again on Lipids in our June 3 issue, bringing critical insights into emerging targeted therapies. In the June 3 Deep Dive, editor-in-chief Harlan M. Krumholz, MD, SM, FACC, reviews…
Vutrisiran Impact on Functional Capacity and QOL | JACC Deep Dive | JACC
Go behind the scenes with JACC as editor-in-chief Harlan M. Krumholz, MD, SM, FACC, talks about what 's caught his attention in the latest JACC issue on amyloid. In this paper by Sheikh et al, the…
Individual Variation in Tirzepatide Response | JACC Deep Dive
Join JACC Editor in Chief Harlan Krumholz, MD, SM, as he speaks about this ACC.25 presentation published in JACC. This fascinating study by Rohan Khera et al independently analyzed patient-level data…
Revisiting the SUMMIT Trial | JACC Deep Dive
This JACC Deep Dive in our May 13 issue highlights new findings from the SUMMIT CKD study, showing that terzepatide improves symptoms, function, and weight in patients with HFpEF and…
1-Year Results of ADVANTAGE AF | JACC Deep Dive
In this JACC Deep Dive episode, Dr. Harlan Krumholz reviews the ADVANTAGE-AF trial, which evaluated pulse field ablation (PFA) as a treatment for persistent atrial fibrillation. The study…
Disentangling the Impact of Adiposity From Insulin Resistance in HFpEF | JACC Deep Dive
In a Deep Dive in our May 13 issue, Editor-in-Chief Harlan Krumholz, MD, SM, FACC, discusses a study led by Barry Borlaug that investigates whether excess weight or metabolic dysfunction has a…
Sudden Cardiac Arrest in Young Athletes | JACC Deep Dive
In this JACC Deep Dive episode, Editor-in-Chief Dr. Harlan Krumholz discusses a major study on sudden cardiac arrest in young competitive athletes, highlighting survival rates, causes, and racial…
Altshock-2 | JACC Deep Dive
In this in-depth analysis of the Altshock-2 trial (Study on Early Intra-aortic Balloon Pump Placement in Acute Decompensated Heart Failure Complicated by Cardiogenic Shock), Harlan M Krumholz, MD,…
Epidemiology and Outcomes in HFimpEF | JACC Deep Dive
In this JACC Deep Dive, Editor-in-Chief Harlan M. Krumholz, MD, SM, discusses a large real-world study by Min et al. examining heart failure with improved ejection fraction (HFimpEF) in over 24,000…
ACURATE neo2 Under-Expansion | JACC Deep Dive
JACC's July 29 issue explores why the ACURATE neo2 valve failed in its IDE trial, with a post-hoc analysis pointing to under-expansion in heavily calcified anatomies as a potential culprit. Though…
Validation of AHA PREVENT in Healthcare Populations | JACC Deep Dive
In this JACC Deep Dive, JACC Editor in Chief Harlan M. Krumholz, MD, SM, explores a study led by Dr. Pradeep Natarajan that evaluates how well the new AHA PREVENT risk equations predict…
Plaque Vulnerability and Risk Factors | JACC Deep Dive
In this JACC Deep Dive, Harlan M. Krumholz, MD, SM, FACC reviews a study by Covani, et al that uses OCT imaging in over 1,500 ACS patients to show how increasing cardiovascular risk factor…
IHCA Incidence Rates | JACC Deep Dive
In this JACC Deep Dive, Harlan M. Krumholz, MD, SM, FACC, discusses a new study in the July 8 issue of JACC, authored by Saket Girotra MD, SM, et al. In the study, which links national registry and…
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JACC Deep Dive has published 20 episodes since June 2025, covering topics in Health & Fitness, Medicine.
JACC Deep Dive is currently dormant with new episodes weekly. Average episode length is 7m.
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