Weight and Metabolism
Dr Deepti Sharma, MD
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The Pleasure Triad — How You Were Wired to Seek Comfort, Conserve Energy, and Avoid Pain
You are not broken. You are not lazy. You are not lacking discipline. You are, in fact, doing exactly what a hundred thousand years of human evolution designed you to do.In Part 4 of this series, Dr.…
Unhealthy Coping Mechanisms or Numbing
If you've ever reached for food when you weren't hungry, poured a drink to take the edge off, scrolled until midnight to avoid your own thoughts, socialized mindlessly, filling your time with plans…
Trauma and ACE
Trauma doesn't just live in memory. It lives in the body — in a nervous system that never got the signal that it was safe to stand down. You may have come to Dr. Deepti Sharma looking for answers…
ACE - Adverse Childhood Experiences and their impact on our health
In this foundational episode, Dr. Sharma — triple board-certified physician, certified Menopause Practitioner, and certified life coach — unpacks adverse childhood experiences from the ground up.…
Contributing Factors to Obesity — Genetics, Epigenetics, Hormones, and Set Point Theory
In the next few episodes, I want to talk about the contributing factors or causes of obesity in detail. The number one thing is genetics. Genetic predisposition plays a foundational role, influencing…
How Your Weight Impacts Your Health
Let's talk about what obesity actually does to your body — not to shame or scare you, but so you understand what's really at stake.In this episode, I walk through the hard science: obesity is an…
The Obesity Epidemic by the Numbers
Let's talk about just how big this problem really is — because the stats are staggering.In 2022, 1 in 8 people globally were diagnosed with obesity. Adult obesity has more than doubled since 1990.…
Stress Eating — Understanding Emotional Eating and How to Break the Cycle
In this episode, let's talk about stress eating, also called emotional eating. It's when you eat in response to emotions rather than physical hunger. It's usually a way to cope with stress, anxiety,…
Glycemic Index — Understanding How Food Affects Blood Sugar
In this episode, I'm talking about glycemic index. The glycemic index is a system that ranks carbohydrate foods based on how quickly they raise your blood sugar levels after being eaten. The scale…
The Doctor Behind the Podcast
In this episode, Dr. Deepti Sharma sits down with Erica Rooney from Walk West to pull back the curtain on why this podcast exists — and what drives her work in obesity and lifestyle medicine.You'll…
Metabolically Healthy vs. Metabolically Unhealthy Obesity
In this episode, we're talking about metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO). These terms describe different metabolic profiles in people with obesity. Despite…
Barriers to Diagnosing and Treating Obesity
Diagnosing and treating obesity is really challenging due to a variety of barriers that can be broadly categorized into patient-related, healthcare provider-related, and systemic barriers. Let's…
The Clinical Workup — Understanding the Whole Person
Obesity is one of the most complicated diseases we face today. By the time people walk into my office, they've already tried multiple diets, cleanses, detoxes, and exercise programs, and they often…
Pathophysiology of Obesity, Part 11 — Environment and Advocacy
So far in this series, we've explored the biology of obesity: genetics, hormones, the gut-brain axis, and set point theory. But biology isn't the whole story. The world we live in, our environment,…
Pathophysiology of Obesity, Part 10 — Yo-Yo Dieting and Weight Cycling
Meet Sarah. Over the last decade, she's tried everything: keto, intermittent fasting, juice cleanses, low-fat diets. Every time, the pattern is the same. She loses 20 pounds, and within months the…
Pathophysiology of Obesity, Part 9 — The Set Point Theory
If you've ever lost weight on a diet only to see it creep back within months, you're not alone. Your experience reflects one of the most important theories in obesity science: the set point theory.…
Pathophysiology of Obesity, Part 8 — Why Your Body Defends Fat Mass
Why is losing weight so hard and keeping it off nearly impossible? The answer lies in how our brain and gut are wired to protect fat mass, just like they protect red blood cells, bone, or muscle…
Pathophysiology of Obesity, Part 7 — Energy Balance and the Gut-Brain Connection
Energy balance sounds simple: calories in versus calories out. But it's actually a delicate conversation between the gut and the brain, orchestrated by the hypothalamus. Your brain and gut are in…
Pathophysiology of Obesity, Part 6 - The Gut-Brain Conversation
Our gut constantly talks to our brain through a symphony of hormones that control hunger, fullness, and energy balance. Some hormones rev up appetite, while others apply the brakes.In this episode,…
Pathophysiology of Obesity, Part 5 - Insulin: The Gatekeeper
When people say "I'm doing everything right, but the weight won't come off," the answer often lies in insulin resistance.Insulin is the key that unlocks your cells so glucose can enter. Once inside,…
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Weight and Metabolism has published 29 episodes since February 2026, covering topics in Health & Fitness, Medicine.
Weight and Metabolism is currently highly active with new episodes weekly. Average episode length is 5m.
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